PROCESS FOR PREPARING 5-HYDROXY-OR 6-HYDROXY-ISOQUINUCLIDINES

1,263,415. Isoquinuclidine ester derivatives. SOC FARMACEUTICI ITALIA. 24 July, 1970 [29 July, 1969], No. 35934/70. Heading C2C. Novel Compounds I in which R is 1-6C alkyl or aralkyl and X and X 1 are different, one being H, the other a radical C 6 H 5 -C(R 1 )(R 2 )-COO-; R 1 is H or OH and R 2 is aryl or cycloalkyl and their acid addition and quaternary ammonium salts are prepared by reacting the appropriate hydroxy-quinuclidine with C 6 H 5 C(R 1 )(R 2 )COCl, followed by salt formation where necessary. If R 1 is OH preferably the hydroxyquinolidine is first reacted with C 6 H 5 C(Cl)(R 2 )COCl to give I where R 1 is Cl followed by hydrolysis to give I where R 1 is OH. Pharmaceutical compositions comprise a Compound I together with a suitable excipient and have antispastic activity.