NON-PEPTIDE GnRH AGENTS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION

Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described. Opisani su nepeptidni GnRH agensi sposobni za inhibiranje efekta hormona koji oslobadja gonadotropin. Takva jedinjenja i njihove farmaceutski prihvatljive soli, multimeri, ciljni lekovi, i aktivni metaboliti pogodni su za lečenje reproduktivnih poremećaja kod sisara i tumora koji su zavisni od steroidnih hormona kao i za regulisanje plodnosti, kada se pokazuje suzbijanje oslobadjanja gonadotropina. Postupci za sintetizovanje jedinjenja i intermedijera korisnih za njihovo dobijanje takodje su opisani.[Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.