TETRAISOQUINOLOLINE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS

Compounds of formula (I), wherein: R represents a substituent selected from: a hydrogen or halogen atom; a hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethanesulfonyloxy, pentafluoroethyl, C1-4alkyl, C1-4alkoxy, arylC1-4alkoxy, C1-4alkylthio, C1-4alkoxyC1-4alkyl, C3-6cycloalkylC1-4alkoxy, C1-4alkanoyl, C1-4alkoxycarbonyl, C1-4alkylsulfonyl, C1-4alkylsulfonyloxy, C1-4alkylsulfonylC1-4alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonylC1-4alkyl, C1-4alkylsulfonamido, C1-4alkylamido, C1-4alkylsulfonamidoC1-4alkyl, C1-4alkylamidoC1-4alkyl, arylsulfonamido, arylcarboxamido, arylsulfonamidoC1-4alkyl, arylcarboxamidoC1-4alkyl, aroyl, aroylC1-4alkyl, or arylC1-4alkanoyl group; a group R OCO(CH2)p, R CON(R )(CH2)p, R R NCO(CH2)p or R R NSO2(CH2)p where each of R and R independently represents a hydrogen atom or a C1-4alkyl group or R R forms part of a C3-6azacyloalkane or C3-6(2-oxo)azacycloalkane ring and p represents zero or an integer from 1 to 4; or a group Ar -Z, wherein Ar represents an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring and Z represents a bond, O, S, or CH2; R represents a hydrogen atom or a C1-4alkyl group; q is 1 or 2; A represents a group of formula -(CH2)r-V-(CH2)s-Ar wherein r and s independently represent an integer from zero to 3 such that the sum of r and s is equal to an integer from 1 to 4; V represents a bond, O or S; Ar represents an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring; or an optionally substituted bicyclic ring system; and salts thereof. The compounds are useful for the treatment of conditions which require modulation of a dopamine receptor such as schizophrenia. L'invention concerne des composés de formule (1), dans laquelle: R représente un substituant choisi parmi: un atome d'hydrogène ou d'halogène; un groupe hydroxy, cyano, nitro, trifluorométhyle, trifluorométhoxy, trifluorométhanesulfonyloxy, pentafluoroéthyle, alkyle C1-4, alkoxy C1-4, alkoxy C1-4 aryle, alkythio C1-4, alkyle C1-4 alkoxy C1-4, alkoxy C1-4 cycloalkyle C3-6, alkanoyle C1-4, alkoxycarbonyle C1-4, alkylsulfonyle C1-4, alkylsulfonyloxy C1-4, alkyle C1-4 alkylsulfonyle C1-4, arylsulfonyle, arylsulfonyloxy, alkyle C1-4 arylsulfonyle, alkylsulfonamido C1-4, alkylamido C1-4, alkyle C1-4 alkylsulfonamido C1-4, alkyle C1-4 alkylamido C1-4, arylsulfonamido, arylcarboxamido, alkyle C1-4 arylsulfonamido, alkyle C1-4 aryl