COLLAGEN PEPTIDES AND USES THEREOF

Collagen peptides, fragments and variants are able to interact with and/or bind integrin alpha 2 beta 1, integrin alpha 1 beta 1 and/or platelet receptor GpVI. Such peptides, mimetics thereof and substances that bind them are useful in modulating platelet and other cell function, including aggregati...

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Bibliographische Detailangaben
Hauptverfasser:	FARNDALE, RICHARD, WILLIAM, BARNES, MICHAEL, JOHN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Collagen peptides, fragments and variants are able to interact with and/or bind integrin alpha 2 beta 1, integrin alpha 1 beta 1 and/or platelet receptor GpVI. Such peptides, mimetics thereof and substances that bind them are useful in modulating platelet and other cell function, including aggregation and activation. L'invention concerne des peptides, des fragments et des variantes de collagène capables d'interagir et/ou de se lier avec l'intégrine alpha 2 beta 1, l'intégrine alpha 1 beta 1, et/ou le récepteur GpVI des plaquettes. Ces peptides, des mimétiques de ces peptides et des substances liant ces peptides sont utiles dans la modulation plaquettaire et autres fonctions cellulaires, notamment l'agrégation et l'activation.