NOVEL GABAB RECEPTOR DNA SEQUENCES

DNA encoding a novel human GABAB receptor subunit, HG20, as well as the protein encoded by the DNA, is provided. Also provided is DNA encoding a novel murine GABAB receptor subunit, GABABR1a, as well as the protein encoded by the DNA. Heterodimers of HG20 protein and GABABR1a protein that form a fun...

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Hauptverfasser:	MCDONALD, TERRENCE, CLARK, JANET, NG, GORDON, YIU, KON, BONNERT, TIMOTHY, P, BONNER, TOM, I, LIU, QUINGYUN, KOLAKOWSKI, LEE, F., JR
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	DNA encoding a novel human GABAB receptor subunit, HG20, as well as the protein encoded by the DNA, is provided. Also provided is DNA encoding a novel murine GABAB receptor subunit, GABABR1a, as well as the protein encoded by the DNA. Heterodimers of HG20 protein and GABABR1a protein that form a functional GABAB receptor are disclosed. Methods of identifying agonists and antagonists of the GABAB receptor are also provided. La présente invention concerne de l'ADN codant une nouvelle sous-unité du récepteur GABAB humain, HG20, ainsi que la protéine codée par ledit ADN. Elle concerne également un ADN codant une nouvelle sous-unité de récepteur GABAB murin, GABABR1a, ainsi que la protéine codée par ledit ADN. Elle concerne encore des hétérodimères de la protéine HG20 et de la protéine GABABR1a qui forment un récepteur GABAB fonctionnel, ainsi que des procédés d'identification d'agonistes et d'antagonistes du récepteur GABAB.