METHOD OF USING IL-11 TO ENHANCE CELL MEDIATED IMMUNITY FOR TREATING VARIOUS VIRAL AND PARASITIC INFECTIONS AND CANCER

Provided by the present invention are methods of treating a variety of diseases where enhancement of cytotoxic T cell activity has shown to be beneficial including acute viral disorders such as influenza, chronic viral disorders such as Epstein-Barr Virus (EBV), human immunodeficiency virus (HIV), h...

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Bibliographische Detailangaben
Hauptverfasser:	DORNER, ANDREW, J, BLISS, JUDITH, L, O'TOOLE, MARGOT, TREPICCHIO, WILLIAM, L
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided by the present invention are methods of treating a variety of diseases where enhancement of cytotoxic T cell activity has shown to be beneficial including acute viral disorders such as influenza, chronic viral disorders such as Epstein-Barr Virus (EBV), human immunodeficiency virus (HIV), herpes, hepatitis, and varicella zoster, parasitic infections such as malaria and tuberculosis, and cancer. In addition, provided by the present invention are methods of ex vivo enhancement of T cell activity from cells derived from patients with the above disorders followed by subsequent reintroduction of the modified cells into the patients. L'invention concerne des procédés de traitement de plusieurs maladies par la stimulation de l'activité des lymphocytes T cytotoxiques. Cette stimulation s'est avérée bénéfique pour les troubles viraux aigus, tels que la grippe, les troubles viraux chroniques, dont le virus Epstein-Barr (EBV), le virus de l'immunodéficience humaine (VIH), l'herpès, l'hépatite et le virus varicelle-zona, les infections parasitaires, notamment la malaria et la tuberculose, ainsi que le cancer. L'invention concerne, en outre, des procédés de stimulation ex vivo de l'activité de lymphocytes T des lymphocytes extraits de cellules dérivées de patients souffrant des troubles précités et de réintroduction dans le patient des cellules modifiées.