VIBRIO CHOLERAE VACCINE CANDIDATES AND METHOD OF THEIR CONSTRUCTING

The present invention relates to new vaccine strains of Vibrio cholerae wherein the mucinase activity coded by the gene of the hemagglutinine protease has been eliminated. Said gene has been interrupted with the insertion of a marquer gene. There is also disclosed another mutant of Vibrio cholerae h...

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Hauptverfasser:	SILVA CABRERA, ANISIA JUANA, RODRIGUEZ GONZALEZ, BORIS LUIS, VALLE DIAZ, EDGAR, FANDO CALZADA, RAFAEL ALFREDO, LEDON PEREZ, TALENA YAMILE, CAMPOS GOMEZ, JAVIER, BENITEZ ROBLES, JORGE ANTONIO
Format:	Patent
Sprache:	eng ; fre ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to new vaccine strains of Vibrio cholerae wherein the mucinase activity coded by the gene of the hemagglutinine protease has been eliminated. Said gene has been interrupted with the insertion of a marquer gene. There is also disclosed another mutant of Vibrio cholerae having better properties of biosecurity. En la presente invención se describen nuevas cepas vacunales de Vibrio cholerae en las cuales se ha eliminado la actividad mucinasa codificada por el gen de la hemaglutinina proteasa. Dicho gen ha sido interrumpido con la inserción de un gen marcador. Se describe otro mutante de Vibrio cholerae con mejores atributos de bioseguridad. L'invention concerne de nouvelles souches de vaccin contre le Vibrio cholerae dont on a supprimé l'activité de la mucine codée par le gène de l'hémagglutinine protéase. On a interrompu ce gène avec l'insertion d'un gène marqueur. L'invention concerne en outre un autre mutant de Vibrio cholerae présentant de meilleures propriétés de biosécurité.