COMPOSITIONS THAT SPECIFICALLY BIND TO COLORECTAL CANCER CELLS AND METHODS OF USING THE SAME

A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colorectal cancer are disclosed as are r...

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Bibliographische Detailangaben
Hauptverfasser:	BARBER, MICHAEL, T, WALDMAN, SCOTT, A, PARKINSON, SCOTT, J, PEARLMAN, JOSHUA, M, SCHULZ, STEPHANIE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colorectal cancer are disclosed as are reagents, kits and methods for identifying adenocarcinomas as colorectal in origin. Compounds, compositions and methods of treating patients with metastasized colorectal cancer and for imaging metastasized colorectal tumors in vivo are disclosed. Compositions and methods for delivering active compounds such as gene therapeutics and antisense compounds to colorectal cells are disclosed. Vaccines compositions and methods of for treating and preventing metastasized colorectal cancer are disclosed. L'invention concerne un produit de transcription unique, CRCA-1, et des produits de traduction variés issus de ce dernier. Le transcrit et ses produits de traduction sont des marqueurs pour les cellules colorectales. L'invention concerne également des réactifs de criblage et de diagnostic, des ensembles et des méthodes pour les cancers colorectaux métastasés ainsi que des réactifs, des ensembles et des techniques permettant de déterminer l'origine colorectale des adénocarcinomes. L'invention concerne en outre des composés, compositions et méthodes permettant de traiter les patients présentant un cancer colorectal métastasé et de visualiser les tumeurs colorectales métastasées in vivo, ainsi que des compositions et des méthodes permettant de distribuer des composés actifs tels que des traitements géniques et des composés antisens dans les cellules colorectales. L'invention concerne enfin des compositions et des méthodes de traitement et de prévention du cancer colorectal métastasé.