NEW METALLOPROTEINASE INHIBITORS, THEIR THERAPEUTIC USE AND PROCESS FOR THE PRODUCTION OF THE STARTING COMPOUND IN THE SYNTHESIS THEREOF

Objects of the present invention are peptido-mimetic compounds having the capacity of acting as inhibitors of metalloproteinases produced by snake venom, and of other metalloproteinases of human origin which have been related with various pathologies in man, including tumoral growth and metastatizat...

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Hauptverfasser: DI STAZIO, GIOVANNI, POCHETTI, GIORGIO, PAGLIALUNGA PARADISI, MARIO, D'ALESSIO, SILVANA, GORINI, BARBARA, SELLA, ANTONIO, PANINI, GABRIELLA, POLITI, VINCENZO, GIORDANO, CESARE, MAZZA, FERNANDO, PIAZZA, CINZIA, CIRILLI, MAURIZIO, GAVUZZO, ENRICO, GALLINA, CARLO
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creator DI STAZIO, GIOVANNI
POCHETTI, GIORGIO
PAGLIALUNGA PARADISI, MARIO
D'ALESSIO, SILVANA
GORINI, BARBARA
SELLA, ANTONIO
PANINI, GABRIELLA
POLITI, VINCENZO
GIORDANO, CESARE
MAZZA, FERNANDO
PIAZZA, CINZIA
CIRILLI, MAURIZIO
GAVUZZO, ENRICO
GALLINA, CARLO
description Objects of the present invention are peptido-mimetic compounds having the capacity of acting as inhibitors of metalloproteinases produced by snake venom, and of other metalloproteinases of human origin which have been related with various pathologies in man, including tumoral growth and metastatization, atherosclerosis, multiple sclerosis, Alzheimer's disease, osteoporosis, hypertension, rheumatoid arthritis and other inflammatory diseases. Object of the present invention is also the procedure for the production of diethylester of (1)-phosphotryptophan, as starting product necessary to synthesize all compounds mentioned above. L'invention porte sur des composés peptido-mimétiques agissant comme inhibiteurs des métalloprotéinases produites par le venin de serpent, et d'autres métalloprotéinases humaines liées chez l'homme à différentes pathologies, dont la croissance et la métastasification des tumeurs, l'athérosclérose, la maladie d'Alzheimer, l'ostéoporose, l'hypertension, l'arthrite rhumatoïde, et autres maladies inflammatoires. L'invention porte également sur le procédé d'obtention de diéthylester de phosphotryptophane servant de produit de départ nécessaire à la synthèse des différents composés mentionnés ci-dessus.
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Object of the present invention is also the procedure for the production of diethylester of (1)-phosphotryptophan, as starting product necessary to synthesize all compounds mentioned above. L'invention porte sur des composés peptido-mimétiques agissant comme inhibiteurs des métalloprotéinases produites par le venin de serpent, et d'autres métalloprotéinases humaines liées chez l'homme à différentes pathologies, dont la croissance et la métastasification des tumeurs, l'athérosclérose, la maladie d'Alzheimer, l'ostéoporose, l'hypertension, l'arthrite rhumatoïde, et autres maladies inflammatoires. 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Object of the present invention is also the procedure for the production of diethylester of (1)-phosphotryptophan, as starting product necessary to synthesize all compounds mentioned above. L'invention porte sur des composés peptido-mimétiques agissant comme inhibiteurs des métalloprotéinases produites par le venin de serpent, et d'autres métalloprotéinases humaines liées chez l'homme à différentes pathologies, dont la croissance et la métastasification des tumeurs, l'athérosclérose, la maladie d'Alzheimer, l'ostéoporose, l'hypertension, l'arthrite rhumatoïde, et autres maladies inflammatoires. L'invention porte également sur le procédé d'obtention de diéthylester de phosphotryptophane servant de produit de départ nécessaire à la synthèse des différents composés mentionnés ci-dessus.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record>
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
TESTING
VINEGAR
WINE
title NEW METALLOPROTEINASE INHIBITORS, THEIR THERAPEUTIC USE AND PROCESS FOR THE PRODUCTION OF THE STARTING COMPOUND IN THE SYNTHESIS THEREOF
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