NEW METALLOPROTEINASE INHIBITORS, THEIR THERAPEUTIC USE AND PROCESS FOR THE PRODUCTION OF THE STARTING COMPOUND IN THE SYNTHESIS THEREOF

Objects of the present invention are peptido-mimetic compounds having the capacity of acting as inhibitors of metalloproteinases produced by snake venom, and of other metalloproteinases of human origin which have been related with various pathologies in man, including tumoral growth and metastatizat...

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Hauptverfasser:	DI STAZIO, GIOVANNI, POCHETTI, GIORGIO, PAGLIALUNGA PARADISI, MARIO, D'ALESSIO, SILVANA, GORINI, BARBARA, SELLA, ANTONIO, PANINI, GABRIELLA, POLITI, VINCENZO, GIORDANO, CESARE, MAZZA, FERNANDO, PIAZZA, CINZIA, CIRILLI, MAURIZIO, GAVUZZO, ENRICO, GALLINA, CARLO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Objects of the present invention are peptido-mimetic compounds having the capacity of acting as inhibitors of metalloproteinases produced by snake venom, and of other metalloproteinases of human origin which have been related with various pathologies in man, including tumoral growth and metastatization, atherosclerosis, multiple sclerosis, Alzheimer's disease, osteoporosis, hypertension, rheumatoid arthritis and other inflammatory diseases. Object of the present invention is also the procedure for the production of diethylester of (1)-phosphotryptophan, as starting product necessary to synthesize all compounds mentioned above. L'invention porte sur des composés peptido-mimétiques agissant comme inhibiteurs des métalloprotéinases produites par le venin de serpent, et d'autres métalloprotéinases humaines liées chez l'homme à différentes pathologies, dont la croissance et la métastasification des tumeurs, l'athérosclérose, la maladie d'Alzheimer, l'ostéoporose, l'hypertension, l'arthrite rhumatoïde, et autres maladies inflammatoires. L'invention porte également sur le procédé d'obtention de diéthylester de phosphotryptophane servant de produit de départ nécessaire à la synthèse des différents composés mentionnés ci-dessus.