COMPOUNDS DERIVED FROM THOPHENE AND BENZOTHIOPHENE, AND RELATED UTILISATION AND COMPOSITION

Compounds derived from thiophene and benzothiophene and related utilisation and composition; the compounds have the formula (I) where Z is -CO-, -CH(OR6), -C(NOR7)-; R1 is H, alkyle C1-C6, halogen, or -O-R12; R2 and R3 are H, alkyle, halogen, nitro or -O-R12 or R2 and R3 are together -CR8=CR9-CR10=C...

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Bibliographische Detailangaben
Hauptverfasser:	DEL CASTILLO NIETO, JUAN CARLOS, MONGE VEGA, ANTONIO, ROCA ACIN, JUAN, BOSCH ROVIRA, ANNA, DEL RIO ZAMBRANA, JOAQUIN, PALOP CUBILLO, JUAN ANTONIO, LASHERAS ALDAZ, BERTA
Format:	Patent
Sprache:	eng ; fre ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds derived from thiophene and benzothiophene and related utilisation and composition; the compounds have the formula (I) where Z is -CO-, -CH(OR6), -C(NOR7)-; R1 is H, alkyle C1-C6, halogen, or -O-R12; R2 and R3 are H, alkyle, halogen, nitro or -O-R12 or R2 and R3 are together -CR8=CR9-CR10=CR11; R4 and R5 are H, alkyle, halogen, haloalkyle, OR12, nitro, -NR13R14; -CO2R12; -SO2NR13R14; -SO2R12; -SR12, cyano; -CONR13R14 or R4 and R5 form together a benzin ring; R6 is H, alkyle, -CO2R12, -C(O)NR13R14 napthyle ou phenyle; R7 is H or alkyle; R8, R9, R10 and R11 are H, alkyle, halogen, -OR12, nitro, cyano, -NR13R14, -COR12, -CO2R12, SO2NR13R14, -SO2R12, -SR12, -CONR13R14; R12 is H, alkyle C1-C6, or phenyle; and R13 and R14 are H, alkyle or phenyle or R13 and R14 form a ring of 5 or 6 members. These compounds are efficient for the treatment of anxiety or depression. Compuestos derivados de tiofeno y benzotiofeno y utilización y composición correspondientes; los compuestos son de fórmula (I) donde Z es -CO-, -CH(OR6)-, -C(NOR7)-; R1 es: H, alquilo C1-C6, halógeno, o -O-R12; R2 y R3 son H, alquilo, halógeno, nitro o -O-R12 o bien R2 y R3 juntos son: -CR8=CR9-CR10=CR11-; R4 y R5 son H, alquilo, halógeno, haloalquilo, -OR12, nitro, -NR13R14; -COR12; -CO2R12; -SO2NR13R14; -SO2R12; -SR12, ciano; -CONR13R14 o bien R4 y R5 forman un anillo de benceno; R6 es: H, alquilo, -CO2R12, -C(O)NR13R14 naftilo o fenilo; R7 es: H o alquilo; R8, R9, R10 y R11 son H, alquilo, halógeno, -OR12, nitro, ciano, -NR13R14, -COR12, -CO2R12, -SO2NR13R14, -SO2R12, -SR12, -CONR13R14; R12 es H, alquilo C1-C6, o fenilo; y R13 y R14 son H, alquilo o fenilo o bien R13 y R14 un anillo de 5 ó 6. Estos compuestos son eficaces para el tratamiento de la ansiedad o de la depresión. L'invention concerne des composés dérivés de thiophène et benzothiophène, leur utilisation et leur composition. Les composés sont de formule (I) dans laquelle Z désigne -CO-, -CH(OR6)-, -C(NOR7)-; R1 désigne H, alkyle en C1-C6, halogène ou -O-R12; R2 et R3 désignent H, alkyle, halogène, nitro ou -O-R12 ou R2 et R3 désignent pris ensemble -CR8=CR9-CR10=CR11; R4 et R5 désignent H, alkyle, halogène, haloalkyle, OR12, nitro, -NR13R14; -COR12; -CO2R12; -SO2NR13R14; -SO2R12; -SR12, cyano; -CONR13R14 ou R4 et R5 forment un noyau benzénique, R6 désigne H, alkyle, -CO2R12, -C(O)NR13R14 napthyle ou phényle; R7 désigne H ou alkyle; R8, R9, R10 et R11 désignent H, alkyle halogène, -OR12, nitro, cyano, -NR13R14, -COR12, -CO2R12, -SO