HYPOLIPIDEMIC BICYCLIC DERIVATIVES

The invention concerns compounds of formula (I) wherein: I is an integer of from 1 to 4; m is an integer of from 0 to 2; R is independently selected from hydrogen, halogen, nitro, hydroxy, phenylalkoxy, C1-4 alkoxy, C1-6 alkyl, -SO3R'', -CO2R'' and -O(CH2)pSO3R'' wherein p is an integer of from 1 to 4 and R'' is hydrogen or C1-6 alkyl, wherein said phenylalkoxy, alkoxy and alkyl groups are optionally substituted by one or more halogen atoms; R is phenyl or pyridyl optionally substituted by one to five groups independently selected from halogen, nitro, hydroxy, phenylalkoxy, C1-4 alkoxy, C1-6 alkyl, -SO3R''', -CO2R''' and -O(CH2)pSO3R''' wherein p is an integer of from 1 to 4 and R''' is hydrogen or C1-6 alkyl, wherein said phenylalkoxy, alkoxy and alkyl groups are optionally substituted by one or more halogen atoms; R is a group independently selected from C1-6 alkyl (including cycloalkyl and cycloalkylalkyl), C2-6 alkenyl, and C2-6 alkynyl which groups are optionally substituted by one or more groups or atoms independently selected from halogen, oxo, C1-4 alkoxy, hydroxy, amino optionally substituted by C1-6 alkyl, thio, and C1-6 alkylthio; R is a group independently selected from C1-6 alkyl (including cycloalkyl and cycloalkylalkyl), C2-6 alkenyl, and C2-6 alkynyl which groups are optionally substituted by one or more groups or atoms independently selected from halogen, oxo, C1-4 alkoxy, hydroxy, amino optionally substituted by C1-6 alkyl, thio, and C1-6 alkylthio; X is CH2 or NH; Y is CH2 or O; and Z is CH or N; provided that when X is CH2, Y is O; and pharmaceutically acceptable derivatives or solvates thereof, to processes for their synthesis, to pharmaceutical compositions containing them and to their use in medicine, particularly as hypolipidemic agents. L'invention concerne les composés selon la formule (I): où I est un nombre entier compris entre 1 et 4; m est un nombre entier situé entre 0 et 2; R est indépendamment sélectionné parmi hydrogène, halogène, nitro, hydroxy, phénylalcoxy, alcoxy C1-4, alkyle C1-6, -SO3R'', -CO2R'' et -O(CH2)pSO3R'' où p est un nombre entier compris entre 1 et 4, et R'' est hydrogène ou alkyle C1-6, où ces groupes phénylalcoxy, alcoxy et alkyle sont éventuellement substitués par un ou plusieurs atomes d'halogène. R représente phényle ou pyridyl éventuellement substitué par un à cinq groupes sélectionnés indépendamment parmi halogène, nitro, hydroxy, phénylalcoxy, alcoxy C1-4, alkyle C1-6, -SO3R''', -CO2R''' et -O(CH2)p