2-(1,2,4-TRIAZOLE-1-YL)-1,3,4-THIADIAZOLE DERIVATIVES HAVING AN EFFECT ON THE C.N.S. AND THE HEART

The invention refers to novel 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives of formula (I) having an influence on the heart and the central nervous system, furthermore pharmaceutical compositions containing the above derivatives, and a process for the preparation of the novel compounds. In formula (I) R represents a hydrogen atom, a C1-4 alkyl group or a phenyl group optionally substituted by 1 to 3 substituents selected from the group defined in the application, Z stands for a hydrogen atom or a C1-4 alkoxy group, R means a group of the formula Alk-NR R wherein Alk is a C1-6 straight or branched chain alkylene group, R and R represent, independently, a hydrogen atom, a C2-6 alkenyl group, a C1-8 alkyl group optionally substituted by a substituent selected from the group defined in the application, or R and R form together with the adjacent nitrogen atom and optionally with one or more further nitrogen and/or oxygen and/or sulfur atom(s) a 5- to 10-membered saturated heterocyclic group, optionally substituted, one of R and R is an amino group, while the other stands for an amino group or a 5- to 10-membered saturated heterocyclic group containing one or more nitrogen and/or oxygen and/or sulfur atom(s) and being linked through its nitrogen atom, said heterocyclic group being optionally substituted or the latter one of R and R means a group of formula -SR wherein R represents a C1-8 alkyl group, a C2-6 alkenyl group or a C2-6 alkinyl group, wherein the alkyl group is optionally substituted by a phenyl group or a halophenyl group, and optionally one or both amino group(s) is/are substituted by 1 or 2 substituent(s) selected from the group consisting of a C1-6 alkyl group, a C2-6 alkenyl group, a phenyl(C1-4 alkyl) group or a halophenyl-(C1-4 alkyl) group. L'invention concerne de nouveaux dérivés de 2-(1,2,4-triazole-1-yl)-1,3,4, thiadiazole représentés par la formule (I) et exerçant une influence sur le coeur et sur le système nerveux central, des compositions pharmaceutiques contenant ces dérivés et un procédé servant à préparer ces nouveaux composés. Dans la formule (I), R représente un atome d'hydrogène, un groupe alkyle C1-4 ou un groupe phényle éventuellement substitué par 1 à 3 substituants sélectionnés dans le groupe défini dans le descriptif; Z représente un atome d'hydrogène ou un groupe alkoxy C1-4, R représente un groupe de formule Alk-NR R dans laquelle Alk représente un groupe alkylène C1-6 à chaîne droite ou ramifiée, R et R représenten