CYCLIC CARBAMATES AND ISOXAZOLIDINES AS IIB/IIIA ANTAGONISTS

This invention relates generally to cyclic carbamates and hydroxylamines which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these...

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Bibliographische Detailangaben
Hauptverfasser:	CONFALONE, PASQUALE, NICHOLAS, JIN, FUQIANG
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention relates generally to cyclic carbamates and hydroxylamines which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders. L'invention porte d'une manière générale sur des carbamates et sur des hydroxylamines cycliques servant d'antagonistes du complexe récepteur de fibrinogène de la glycoprotéine plaquettaire IIB/IIIA, sur des préparations pharmaceutiques contenant lesdits composés, sur leur procédé de préparation et sur des procédés d'utilisation de ces composés pour empêcher l'agrégation plaquettaire, sur leur utilisation comme thrombolytiques et/ou pour le traitement de troubles d'ordre thromboemboliques.