PHARMACEUTICAL PRODUCTS FOR CURING AND PREVENTING ILLNESSES CONNECTED WITH THE MALFUNCTION OF VASCULAR ENDOTHELIAL CELLS

The invention relates to the use of certain hydroxylamine derivatives in the therapy or prevention of illnesses connected with the dysfunction of the vascular endothelial cells. Another object of the invention is the use of the same compounds in the preparation of pharmaceutical compositions against the above diseases. In general formulae (I) and (II), R and R independently refer to a hydrogen atom or a straight or branched alkyl group of 1 to 6 carbon atoms, or R and R together with the nitrogen atom in-between form a saturated 5 - 7 membered heterocyclic group, containing optionally further nitrogen and/or oxygen heteroatoms, A refers to a straight or branched alkyl group of 4 to 12 carbon atoms, a phenyl group, substituted or unsubstituted, containing preferably an alkyl-, haloalkyl- or nitro group as substituent, or a 5 - 6 membered heteroaromatic ring containing nitrogen, oxygen or sulphur, in general formula (I), Z refers to a covalent bond, and in general formula (II) to a covalent bond or a =NH group, in general formula (I), X refers to a halogen atom or to a - NR R group, wherein R and R independently refer to a hydrogen atom or a straight or branched alkyl group of 1 to 6 carbon atoms, while in general fomrula (II) X refers to an oxygen atom, in general formula (II), R' refers to a hydrogen atom or a straight or branched alkyl group of 1 to 6 carbon atoms, and in general formulae (I) and (II), Y refers to a hydrogen atom, a hydroxyl group or an acyloxy group, which contains preferably the acyl part of a long chain fatty acid of 8 to 22 carbon atoms, or of a cyclic aromatic carboxylic acid as its acyl component, and in the compounds of general formula (I) wherein X refers to a - NR R group and Y refers to a hydroxyl group, the X group is condensed with the Y substituent and forms the intramolecular ring represented by general formula (III), in which formula A, Z, R and R have the same reference as above. La présente invention concerne l'emploi de certains dérivés hydroxilamine dans la prévention ou la thérapie de maladies liées au dysfonctionnement de cellules de l'endothélium vasculaire. Un autre objet de l'invention est l'emploi des mêmes composés dans la préparation de composés pharmaceutiques soignant ces maladies. Dans les formules générales (I) et (II), R et R représentent indépendamment l'un de l'autre un atome d'hydrogène ou un groupe alkyl droit ou ramifié portant 1 à 6 atomes de carbone, ou R et R forment ensemble avec l'atome d'azote in