AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN

AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN

The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula (I): wherein W, W , W , and W are selected from CH and N, provided that one of W and W is C(C(=NH)NH2) and at most two of W, W , W , and W are N and one of J and J is substituted by -(CH2)n-Z-A-B, which a...

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Hauptverfasser: HAN, QI, QUAN, MIMI, LIFEN, DOMINGUEZ, CELIA, DUFFY, DANIEL, EMMETT, PARK, JEONGSOOK, MARIA, ROSSI, KAREN, ANITA, WEXLER, RUTH, RICHMOND
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula (I): wherein W, W , W , and W are selected from CH and N, provided that one of W and W is C(C(=NH)NH2) and at most two of W, W , W , and W are N and one of J and J is substituted by -(CH2)n-Z-A-B, which are useful as inhibitors of factor Xa or thrombin. La présente demande concerne des amidinoindoles, des amidinoazoles et leurs analogues répondant à la formule (I), où W, W , W et W sont choisis parmi CH et N, à condition que l'un des éléments W et W soit C(C(=NH)NH2), que deux au plus des éléments W, W , W et W soient N, et que l'un des éléments J et J soit substitué par -(CH2)n-Z-A-B, et pouvant être utiles en tant qu'inhibiteurs du facteur Xa ou de la thrombine.