PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS

Provided are particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain. Also provided are compositions comprising such particles, including pharmaceutical compositions, methods of making the present particles, and methods of using such particles, for...

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Bibliographische Detailangaben
Hauptverfasser: HUANG, HAIYONG, THURMOND, K., BRUCE, II, WOOLEY, KAREN, L, WARNER, JAMES, M
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Provided are particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain. Also provided are compositions comprising such particles, including pharmaceutical compositions, methods of making the present particles, and methods of using such particles, for example for delivery of pharmaceutically active agents. L'invention concerne des particules comprenant des copolymères amphiphiles, possédant un domaine d'enveloppe réticulé et un domaine de noyau interne. Des compositions sont également décrites qui englobent de telles particules, y compris des compositions pharmaceutiques, des procédés de fabrication des présentes particules et des procédés d'utilisation de telles particules pour l'administation, par exemple, d'agents pharmacologiquement actifs.