ANTICOAGULANT PEPTIDE FRAGMENTS DERIVED FROM APOLIPOPROTEIN B-100

The present invention provides a peptide compound of formula Z -K-A-Q-X -K-K-N-K-H-R-H-S-X -T-Z [SEQ ID No. 1] where: X represents S or Y, X represents T or I, Z represents the N terminus of the peptide, or from 1 to 47 amino acids, Z represents the C terminus of the peptide, a terminal amide group,...

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Bibliographische Detailangaben
Hauptverfasser:	BRUCKDORFER, KARL, RICHARD, ETTELAIE, CAMILLE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a peptide compound of formula Z -K-A-Q-X -K-K-N-K-H-R-H-S-X -T-Z [SEQ ID No. 1] where: X represents S or Y, X represents T or I, Z represents the N terminus of the peptide, or from 1 to 47 amino acids, Z represents the C terminus of the peptide, a terminal amide group, or from 1 to 77 amino acids; or a variant of this peptide which contains one or more internal deletions, insertions or substitutions and which substantially retains anti-coagulant properties of apoB-100. La présente invention concerne un composé peptidique selon la formule Z -K-A-Q-X -K-K-N-K-H-R-H-S-X -T-Z . Dans cette dernière, X représente S ou Y, X représente T ou I, Z représente l'extrémité N du peptide, ou entre 1 et 47 acides aminés, Z représente l'extrémité C du peptipe, un groupe terminal amide, ou entre 1 et 77 acides aminés. L'invention traite aussi d'une variante de ce peptide qui contient une ou plusieurs appauvrissements internes, insertions ou substitutions et qui conserve sensiblement les propriétés anticoagulantes de apoB-100.