CALIXPYRROLES, CALIXPYRIDINOPYRROLES AND CALIXPYRIDINES

The present invention provides calixpyrrole, calixpyridinopyrrole, and calixpyridine macrocycles, having 4, 5, 6, 7, or 8 heterocyclic rings, as well as syntheses, derivatives, conjugates, multimers, and solid supports thereof. Such macrocycles have proved to be effective and selective ion- and neut...

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Hauptverfasser:	SESSLER, JONATHAN, L, GENGE, JOHN, W, BROWN, CHRISTOPHER, T, LYNCH, VINCENT, GALE, PHILIP, A, SANSOM, PETRA, I, ANDRIEVSKY, ANDREI, GEBAUER, ANDREAS, KRAL, VLADIMIR, ALLEN, WILLIAM, E
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY DECONTAMINATION ARRANGEMENTS THEREFOR DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEAR ENGINEERING NUCLEAR PHYSICS NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULARRADIATION OR PARTICLE BOMBARDMENT SEPARATION SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS TESTING THEIR RELEVANT APPARATUS TRANSPORTING TREATING RADIOACTIVELY CONTAMINATED MATERIAL
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Beschreibung
Zusammenfassung:	The present invention provides calixpyrrole, calixpyridinopyrrole, and calixpyridine macrocycles, having 4, 5, 6, 7, or 8 heterocyclic rings, as well as syntheses, derivatives, conjugates, multimers, and solid supports thereof. Such macrocycles have proved to be effective and selective ion- and neutral molecule-binding agents forming supramolecular ensembles, and ion- and neutral molecule-separation agents. The macrocycles are fully meso-non-hydrogen-substituted porphyrinogens, a few molecules of which were previously known but not recognized as possessing anion- or molecule-binding properties. The binding mode is noncovalent, primarily that of hydrogen-bonding, thereby providing a new mode for liquid chromatography, that of Hydrogen Bonding Liquid Chromatography. Further useful applications of the macrocycles provided herein include environmental remediation by removal of undesired ions or neutral molecules, and removal of phosphate for kidney dialysis. L'invention concerne des macrocycles calixpyrroles, calixpyridinopyrroles et calixpyridines, possédant 4, 5, 6, 7 ou 8 noyaux hétérocycliques, ainsi que leurs synthèses, dérivés, conjugués, multimères et supports solides. Ces macrocycles se sont avérés être des agents de liaison des ions et des molécules neutres efficaces et sélectifs, formant des ensembles supramoléculaires, ainsi que des agents de séparation des ions et des molécules neutres. Ils constituent des porphyrinogènes totalement méso, sans substituant hydrogène dont certaines molécules étaient déjà connues, mais pas les propriétés de liaison anionique ou moléculaire de celles-ci. Le mode de liaison, non covalent, est à l'origine une liaison hydrogène, ce qui donne un nouveau procédé de chromatographie en phase liquide, la chromatographie en phase liquide par liaison hydrogène. Parmi les autres applications utiles des macrocycles cités ici, on trouve le traitement de l'environnement par élimination des ions ou des molécules neutres indésirables, et l'élimination des phosphates en dialyse rénale.