PROCESS FOR INCREASING THE PRODUCTION OF PENICILLIN G (BENZYLPENICILLIN) IN PENICILLIUM CHRYSOGENUM THROUGH THE EXPRESSION OF THE GENE pcl

Process for increasing the production of penicillin G (benzylpenicillin) in Penicillium chrysogenum through the expression of the gene pcl. The gene pcl codes for the enzyme phenylacetyl-CoA ligase. Through recombinant DNA techniques, the gene pcl obtained from Pseudomonas putida U and characterized...

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Hauptverfasser:	MINAMBRES RODRIGUEZ, BALTASAR, MORENO VALLE, MIGUEL ANGEL, GARCIA ALONSO, BELEN, DIEZ GARCIA, BRUNO, MARTINEZ BLANCO, HONORINA, SALTO MALDONADO, FRANCISCO, FERNANDEZ CANON, JOSE MANUEL, LUENGO RODRIGUEZ, JOSE MARIA, RODRIGUEZ OLIVERA, ELIAS, BARREDO FUENTE, JOSE LUIS, SCHLEISSNER SANCHEZ, CARMEN
Format:	Patent
Sprache:	eng ; fre ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Zusammenfassung:	Process for increasing the production of penicillin G (benzylpenicillin) in Penicillium chrysogenum through the expression of the gene pcl. The gene pcl codes for the enzyme phenylacetyl-CoA ligase. Through recombinant DNA techniques, the gene pcl obtained from Pseudomonas putida U and characterized by the sequence SEQ ID NO: 1 is introduced, and new transformed mutants CECT 20192 are obtained, which produce an increase of at least 10 % of penicillin G with respect to untransformed control strains.