INHIBITION OF AMYLOIDOSIS BY 9-ACRIDINONES

Amyloid aggregation in animals is inhibited by administering a 9-acridinone compound of formula (I), wherein R and R are hydrogen, halo, nitro, amino, hydroxy, trifluoromethyl, alkyl, alkoxy, and alkylthio; R is hydrogen or alkyl; and R is -alkylene-NR R . The compounds are especially useful in prev...

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Bibliographische Detailangaben
Hauptverfasser:	LEVINE, HARRY, III, HAYS, SHERYL, JEANNE, SCHOLTEN, JEFFREY, DAVID
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	Amyloid aggregation in animals is inhibited by administering a 9-acridinone compound of formula (I), wherein R and R are hydrogen, halo, nitro, amino, hydroxy, trifluoromethyl, alkyl, alkoxy, and alkylthio; R is hydrogen or alkyl; and R is -alkylene-NR R . The compounds are especially useful in preventing and treating Alzheimer's disease. On inhibe l'agrégation amyloïde chez l'animal en administrant un composé de 9-acridinone de formule (I), dans laquelle R et R sont hydrogène, halo, nitro, amino, hydroxy, trifluorométhyle, alkyle, alcoxy et alkylthio; R est hydrogène ou alkyle, et R est -alkylène-NR R . Ces composés sont particulièrement utiles dans la prévention et le traitement de la maladie d'Alzheimer.