METHOD FOR THE INTRANASAL ADMINISTRATION OF L-DOPA PRODRUGS

The esterification of the carboxylic group of L-dopa resulted in derivatives (prodrugs) that are considerably more water soluble and more lipophilic than L-dopa. The esters were found a) to be absorbed rapidly from the nasal cavity of the rat, b) to be rapidly hydrolyzed to L-dopa in rat plasma, bra...

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Bibliographische Detailangaben
Hauptverfasser: KAO, HUAIHUNG, DANNY, ITOH, SOICHI, HUSSAIN, ANWAR, A, DITTERT, LEWIS
Format: Patent
Sprache:eng ; fre
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