PARAINFLUENZA VIRUS GLYCOPROTEINS AND VACCINES

PCT No. PCT/CA96/00639 Sec. 371 Date Aug. 7, 1998 Sec. 102(e) Date Aug. 7, 1998 PCT Filed Sep. 23, 1996 PCT Pub. No. WO97/11093 PCT Pub. Date Mar. 27, 1997In summary of this disclosure, the present invention provides hemagglutinin-neuraminidase (HN) and Fusion (F) glycoproteins isolated and purified...

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Hauptverfasser:	EWASYSHYN, MARY, E, KLEIN, MICHEL, H, SYMINGTON, ALISON, L, JACKSON, GAIL, E., D, CATES, GEORGE, A, FAHIM, RAAFAT, E., F
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	PCT No. PCT/CA96/00639 Sec. 371 Date Aug. 7, 1998 Sec. 102(e) Date Aug. 7, 1998 PCT Filed Sep. 23, 1996 PCT Pub. No. WO97/11093 PCT Pub. Date Mar. 27, 1997In summary of this disclosure, the present invention provides hemagglutinin-neuraminidase (HN) and Fusion (F) glycoproteins isolated and purified from parainfluenza viruses types 1, 2 and 3, methods of producing the same, and uses thereof in immunogenic compositions and diagnostic embodiments. In particular, a trivalent vaccine containing HN and F glycoproteins from PIV-1, PIV-2 and PIV-3 generated an immune response capable of neutralizing each of the virus types. Modifications are possible within the scope of the invention.