METHOD FOR THE ISOLATION OF LIPOPROTEIN (A) ALLOWING FOR THE SUBSEQUENT QUANTIFICATION OF ITS MASS AND CHOLESTEROL CONTENT

A method for preparing lipoprotein (a) (Lp(a)) and identifying one or more isoforms of Lp(a) in a biological fluid sample is provided, where the sample is substantially free of lipoproteins of another class, and involves subjecting the sample to ultracentrifugation and subsequently removing interfer...

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Bibliographische Detailangaben
Hauptverfasser:	CHRISTOPHER, C., WILLIAM, GEBSKI, CHRISTINE, OLLINGTON, JAMES, F
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
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Beschreibung
Zusammenfassung:	A method for preparing lipoprotein (a) (Lp(a)) and identifying one or more isoforms of Lp(a) in a biological fluid sample is provided, where the sample is substantially free of lipoproteins of another class, and involves subjecting the sample to ultracentrifugation and subsequently removing interfering substances. A standardized reference for measuring Lp(a) is also described containing one or more isoforms of Lp(a). La présente invention concerne un procédé de préparation de la lipoprotéine (a) (Lp(a) et d'identification d'une ou plusieurs isoformes de Lp(a)) dans un échantillon de liquide biologique, l'échantillon étant sensiblement exempt de lipoprotéines d'une autre classe. Ce procédé comprend l'ultracentrifugation de l'échantillon, suivie de l'enlèvement des substances indésirables. Une référence normalisée pour la mesure de Lp(a), comprenant une ou plusieurs isoformes de Lp(a) est également décrite.