SUBSTITUTED N-CYCLOALKYLMETHYL-1H-PYRAZOLO[3,4-b]QUINOLIN-4 AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF
Substituted N-cycloalkylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance, and d) treating angina p...
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| creator | DORITY, JOHN, A., JR KUMAR, VIRENDRA |
| description | Substituted N-cycloalkylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance, and d) treating angina pectoris, congestive heart disease and myocardial infarction utilizing them.
On décrit des N-cycloalkylméthyl-1H-pyrazolo [3,4-b] quinolin-4-amines à substitution, des compositions pharmaceutiques les contenant et des procédés les utilisant pour: a) inhiber la c-GMP-phosphodiestérase, b) traiter l'insuffisance cardiaque et/ou l'hypertension, c) inverser ou à réduire la tolérance induite par le nitrate et d) traiter l'angine de poitrine, les maladies cardiaques congestives et l'infarctus du myocarde. |
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On décrit des N-cycloalkylméthyl-1H-pyrazolo [3,4-b] quinolin-4-amines à substitution, des compositions pharmaceutiques les contenant et des procédés les utilisant pour: a) inhiber la c-GMP-phosphodiestérase, b) traiter l'insuffisance cardiaque et/ou l'hypertension, c) inverser ou à réduire la tolérance induite par le nitrate et d) traiter l'angine de poitrine, les maladies cardiaques congestives et l'infarctus du myocarde.</description><edition>6</edition><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960919&DB=EPODOC&CC=WO&NR=9628446A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960919&DB=EPODOC&CC=WO&NR=9628446A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DORITY, JOHN, A., JR</creatorcontrib><creatorcontrib>KUMAR, VIRENDRA</creatorcontrib><title>SUBSTITUTED N-CYCLOALKYLMETHYL-1H-PYRAZOLO[3,4-b]QUINOLIN-4 AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF</title><description>Substituted N-cycloalkylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance, and d) treating angina pectoris, congestive heart disease and myocardial infarction utilizing them.
On décrit des N-cycloalkylméthyl-1H-pyrazolo [3,4-b] quinolin-4-amines à substitution, des compositions pharmaceutiques les contenant et des procédés les utilisant pour: a) inhiber la c-GMP-phosphodiestérase, b) traiter l'insuffisance cardiaque et/ou l'hypertension, c) inverser ou à réduire la tolérance induite par le nitrate et d) traiter l'angine de poitrine, les maladies cardiaques congestives et l'infarctus du myocarde.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi0EKwjAQAHvxIOof9gHmUBuKPcY0JcE0W5sEiSKlSjxJLdT_I6IP8DQwzMyTwfqddcp5J0owhAeukel90LVwMmiSStKElp1Q4zlbU3K9HLwyqJUhFFitjLDATAkc6watcgrNV3x-LC1gBd4KcFK0AqtlMrv3jymuflwkUAnHJYnjs4vT2N_iEF_dEYt8s6U0Z2n2R_IGZdY3nA</recordid><startdate>19960919</startdate><enddate>19960919</enddate><creator>DORITY, JOHN, A., JR</creator><creator>KUMAR, VIRENDRA</creator><scope>EVB</scope></search><sort><creationdate>19960919</creationdate><title>SUBSTITUTED N-CYCLOALKYLMETHYL-1H-PYRAZOLO[3,4-b]QUINOLIN-4 AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF</title><author>DORITY, JOHN, A., JR ; KUMAR, VIRENDRA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO9628446A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>1996</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DORITY, JOHN, A., JR</creatorcontrib><creatorcontrib>KUMAR, VIRENDRA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DORITY, JOHN, A., JR</au><au>KUMAR, VIRENDRA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED N-CYCLOALKYLMETHYL-1H-PYRAZOLO[3,4-b]QUINOLIN-4 AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF</title><date>1996-09-19</date><risdate>1996</risdate><abstract>Substituted N-cycloalkylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance, and d) treating angina pectoris, congestive heart disease and myocardial infarction utilizing them.
On décrit des N-cycloalkylméthyl-1H-pyrazolo [3,4-b] quinolin-4-amines à substitution, des compositions pharmaceutiques les contenant et des procédés les utilisant pour: a) inhiber la c-GMP-phosphodiestérase, b) traiter l'insuffisance cardiaque et/ou l'hypertension, c) inverser ou à réduire la tolérance induite par le nitrate et d) traiter l'angine de poitrine, les maladies cardiaques congestives et l'infarctus du myocarde.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUBSTITUTED N-CYCLOALKYLMETHYL-1H-PYRAZOLO[3,4-b]QUINOLIN-4 AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF |
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