SUBSTITUTED N-CYCLOALKYLMETHYL-1H-PYRAZOLO[3,4-b]QUINOLIN-4 AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF

SUBSTITUTED N-CYCLOALKYLMETHYL-1H-PYRAZOLO[3,4-b]QUINOLIN-4 AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF

Substituted N-cycloalkylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance, and d) treating angina p...

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Bibliographische Detailangaben
Hauptverfasser: DORITY, JOHN, A., JR, KUMAR, VIRENDRA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Substituted N-cycloalkylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance, and d) treating angina pectoris, congestive heart disease and myocardial infarction utilizing them. On décrit des N-cycloalkylméthyl-1H-pyrazolo [3,4-b] quinolin-4-amines à substitution, des compositions pharmaceutiques les contenant et des procédés les utilisant pour: a) inhiber la c-GMP-phosphodiestérase, b) traiter l'insuffisance cardiaque et/ou l'hypertension, c) inverser ou à réduire la tolérance induite par le nitrate et d) traiter l'angine de poitrine, les maladies cardiaques congestives et l'infarctus du myocarde.