NON-PEPTIDIC SURROGATES OF ARG-GLY-ASP SEQUENCE AND USE

NON-PEPTIDIC SURROGATES OF ARG-GLY-ASP SEQUENCE AND USE

Non-peptidic analogs of the Arg-Gly-Asp sequence, comprising a guanadine and a carboxyl terminal group spaced by a chain of 11 atoms, at least 5 of which are carbon atoms, are proposed for use in the preparation of pharmaceutical compositions for the prevention and/or treatment of hepatic fibrosis a...

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Bibliographische Detailangaben
Hauptverfasser: LIDER, OFER, HERSHKOVIZ, RAMI, GREENSPOON, NOAM
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Non-peptidic analogs of the Arg-Gly-Asp sequence, comprising a guanadine and a carboxyl terminal group spaced by a chain of 11 atoms, at least 5 of which are carbon atoms, are proposed for use in the preparation of pharmaceutical compositions for the prevention and/or treatment of hepatic fibrosis and cirrhosis. Il est proposé d'utiliser des analogues non peptidiques de la séquence Arg-Gly-Asp comprenant un groupe guanidino et un groupe terminal carboxyle espacés par une chaîne de 11 atomes, dont au moins 5 sont des atomes de carbone, pour la préparation de compositions pharmaceutiques utilisables dans la prévention et/ou le traitement de la fibrose et de la cirrhose hépatiques.