3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS

The invention provides compounds according to formula (I), in which: Ha = I or Br, X = CH2 or C = O, R = C1-4 alkyl, R = -NHSO2R ; -NHCOR ; or -NHCONHR , where R = -CF3, C1-3 alkyl, 4-R C6H4-; where R = C1-4 alkoxy-; hydroxy-; fluoro-; or nitro-; or a pharmaceutically acceptable salt thereof. The co...

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Bibliographische Detailangaben
1. Verfasser:	MELLIN, CHARLOTTA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides compounds according to formula (I), in which: Ha = I or Br, X = CH2 or C = O, R = C1-4 alkyl, R = -NHSO2R ; -NHCOR ; or -NHCONHR , where R = -CF3, C1-3 alkyl, 4-R C6H4-; where R = C1-4 alkoxy-; hydroxy-; fluoro-; or nitro-; or a pharmaceutically acceptable salt thereof. The compounds may particularly be used in the treatment of T3 regulated gene disorders and diseases. L'invention concerne des composés selon la formule (I), ou un sel de ceux-ci, acceptable sur le plan pharmaceutique, dans laquelle: Ha = I ou Br; X = CH2 ou C = O; R = alkyle C1-4; R = -NHSO2R , -NHCOR ou -NHCONHR , où R = -CF3, alkyle C1-3, 4-R C6H4-; où R = alcoxy C1-4, hydroxy, fluoro ou nitro.