ASP INSULIN ANALOGS

Analogs of humain insulin containing an aspartic acid at position 1 of the B chain (Asp), and optionally, having a gln modification at position 13 (Gln), display modified physico-chemical and pharmacokinetic properties which enable them to be long acting. These analogs are useful in the treatment of...

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Bibliographische Detailangaben
Hauptverfasser:	BAKAYSA, DIANE, LEE, BREMS, DAVID, NETTLESHIP
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Analogs of humain insulin containing an aspartic acid at position 1 of the B chain (Asp), and optionally, having a gln modification at position 13 (Gln), display modified physico-chemical and pharmacokinetic properties which enable them to be long acting. These analogs are useful in the treatment of hyperglycemia because they are soluble and display an increased tendency to self-associate. Cette invention se rapporte à des analogues de l'insuline humaine, qui contiennent un acide aspartique à la position 1 de la chaine B (Asp), et qui présentent éventuellement une modification gln à la position 13 (Gln). Ces composés ont des propriétés physicochimiques et pharmacocynétiques modifiées, qui leur permettent d'être actifs longtemps. Ces analogues sont utiles dans le traitement de l'hyperglycémie, parce qu'ils sont solubles et qu'ils ont une tendance accrue à s'auto-associer.