VITAMIN E AND DERIVATIVES PREVENT DAMAGE IN RED CELLS STERILIZED BY PHTHALOCYANINES AND LIGHT

Disclosed is an improved process for irradiating cell-containing compositions, especially, red cell-containing compositions, wherein vitamin E or a derivative thereof is added to the cell-containing composition prior to, during or after such irradiation. Addition of vitamin E or a derivative thereof...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	RYWKIN, SHANTI, BEN-HUR, EHUD, HOROWITZ, BERNARD
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Disclosed is an improved process for irradiating cell-containing compositions, especially, red cell-containing compositions, wherein vitamin E or a derivative thereof is added to the cell-containing composition prior to, during or after such irradiation. Addition of vitamin E or a derivative thereof is protective of cells in such compositions, but not of virus. Cells irradiated using the inventive process show a reduced leakage of K from cells and also a reduced loss of negative charges from the cell membrane compared to cells subjected to the similar process wherein vitamin E or a derivative thereof are not used. In addition, red blood cells sterilized by this process are better preserved during storage and their life-time in the circulation in vivo is greatly enhanced. L'invention concerne un procédé amélioré d'exposition à des rayons de composition contenant des globules, en particulier des globules rouges, procédé selon lequel on ajoute de la vitamine E ou un dérivé de celle-ci à la composition contenant les globules, avant ou après exposition aux rayons. L'addition de vitamine E ou d'un de ses dérivés protège les globules contenus dans de telles compositions, mais non les virus. Les globules exposés au rayonnement conformément au procédé selon l'invention présentent une fuite réduite de K et également une perte réduite de charges négatives à partir de leur membrane, si l'on compare avec des globules soumis à un procédé similaire n'impliquant pas l'utilisation de la vitamine E ou d'un de ses dérivés. En outre, les globules rouges stérilisés selon ce procédé ont une meilleure aptitude au stockage et leur durée de vie in vivo est nettement augmentée.