NOVEL HUMAN LEUKOCYTE ELASTASE (HLE) INHIBITORS, AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE

Novel therapeutic agents useful as inhibitors of HLE are provided. The compounds have structural formula (I) wherein R through R , m, n and p are as defined herein. Methods of using the compounds of formula (I) to inhibit serine proteases and to treat physiological conditions and disease states asso...

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Bibliographische Detailangaben
Hauptverfasser:	LAIBELMAN, ALAN, RYAN, KENNETH, J, HIEBERT, CHARLES, K
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Novel therapeutic agents useful as inhibitors of HLE are provided. The compounds have structural formula (I) wherein R through R , m, n and p are as defined herein. Methods of using the compounds of formula (I) to inhibit serine proteases and to treat physiological conditions and disease states associated with elevated HLE levels are also provided, as are pharmaceutical compositions containing the compounds. L'invention concerne de nouveaux agents thérapeutiques utiles en tant qu'inhibiteurs de HLE. Les composés présentent la formule structurelle (I), dans laquelle R à R , m, n et p sont définis dans la description. L'invention concerne également des procédés d'utilisation des composés de la formule (I) afin d'inhiber des sérine-protéases et afin de traiter des états physiologiques ainsi que des états pathologiques associés à des niveaux élevés de HLE, ainsi que des compositions pharmaceutiques contenant lesdits composés.