MYCOBACTERIA VIRULENCE FACTORS AND A METHOD FOR THEIR IDENTIFICATION

The present invention provides polynucleotides associated with virulence in mycobacteria, and particularly a fragment of DNA isolated from M. bovis that contains a region encoding a putative sigma factor. Also provided are methods for a DNA sequence or sequences associated with virulence determinant...

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Bibliographische Detailangaben
Hauptverfasser:	PASCOPELLA, LISA, DE LISLE, GEOFFREY, W, KAWAKAMI, RIKU, PAMELA, COLLINS, DESMOND, MICHAEL, BLOOM, BARRY, R, JACOBS, WILLIAM, R., JR
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides polynucleotides associated with virulence in mycobacteria, and particularly a fragment of DNA isolated from M. bovis that contains a region encoding a putative sigma factor. Also provided are methods for a DNA sequence or sequences associated with virulence determinants in mycobacteria, and particularly in M. tuberculosis and M. bovis. The invention also provides corresponding polynucleotides associated with avirulence in mycobacteria. In addition, the invention provides a method for producing strains with altered virulence or other properties which can themselves be used to identify and manipulate individual genes. L'invention concerne des polynucléotides associés à la virulence dans des mycobactéries, et plus particulièrement un fragment d'ADN isolé à partir de M. bovis qui contient une région codant un facteur sigma putatif. L'invention porte également sur des procédés destinés à une séquence d'ADN ou à des séquences associées aux déterminants de virulence dans des mycobactéries, et plus particulièrement dans M. tuberculosis et M. bovis. De plus, l'invention se rapporte aux polynucléotides correspondants associés à l'avirulence dans des mycobactéries, et à un procédé de production de souches présentant une virulence modifiée ou d'autres propriétés pouvant être utilisées pour identifier et manipuler des gènes individuels.