N-(3-(3-(1-PIPERIDINYLMETHYL)PHENOXY)PROPYL) HYDROXYACETAMIDE-2-HYDROXY-1,2,3-PROPENETRICARBOXYLATE BISMUTH (3<+>) COMPLEX AND THE METHOD FOR PREPARATION

N-(3-(3-(1-PIPERIDINYLMETHYL)PHENOXY)PROPYL) HYDROXYACETAMIDE-2-HYDROXY-1,2,3-PROPENETRICARBOXYLATE BISMUTH (3<+>) COMPLEX AND THE METHOD FOR PREPARATION

The N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl) hydroxyacetamide-2-hydroxy-1,2,3-propenetricarboxylate bismuth (3) complex (1:1:1) with formula (II) is obtained as a result of the interaction between N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl) hydroxyacetamide and bismuth citrate in a boiling wate...

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Hauptverfasser: ANEVA, VENETA, TIANKOVA, LUTAKOV, GEORGI, IORDANOV, TODOROV, BOJIDAR, TODOROV, TASKOV, MILE, VASSILEV, SCHOPOVA, SAVELINA, IVANOVA, PETKOV, ORLIN, VESELINOV, BACHVAROVA, ANI, SIDEROVA, IVANOV, CHAVDAR, BORISSOV, GALABOVA, ANTOANETA, ANGELOVA, NIKOLOV, GEORGI, NIKOLOV, KAZANDJIEVA, PENKA, ALEKSANDROVA, TOMOVA, VIOLETA, VASSILEVA, ATANASSOVA, RALITZA, BOIANOVA, MONDESCHKA, DONKA, MINKOVA, NINOVA, EVDOKIA, ASSENOVA, ORACHEV, VESSELIN, LIUBOMIROV
Format: Patent
Sprache:eng ; fre
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl) hydroxyacetamide-2-hydroxy-1,2,3-propenetricarboxylate bismuth (3) complex (1:1:1) with formula (II) is obtained as a result of the interaction between N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl) hydroxyacetamide and bismuth citrate in a boiling water. The bismuth salt (II) possesses a high antisecretory and cytoprotective activity, as well as an antibacterial effect against Helicobacter pylori, and is used in tablet form or as capsules for the treatment of gastric and duodenal ulcers. On obtient le complexe (1:1:1) de bismuth (3) de N-(3-(3-(1-pipéridinylméthyl)phénoxy)propyl) hydroxyacétamide-2-hydroxy-1,2,3-propènetricarboxylate de formule (II) par interaction entre du N-(3-(3-(1-pipéridinylméthyl)phénoxy)propyl) hydroxyacétamide et du citrate de bismuth dans de l'eau bouillante. Le sel de bismuth de formule (II) qui présente une activité antisécrétoire et cytoprotective élevée et produit un effet antibactérien contre l'Hélicobacter pylori est utilisé sous forme de comprimés ou de capsules pour le traitement d'ulcères gastriques ou duodénaux.