AN ANTIVIRALLY ACTIVE PHARMACEUTICAL OIL-IN-WATER EMULSION CONTAINING 9-[(2-HYDROXYETHOXY)METHYL]GUANINE (ACYCLOVIR) OR A SALT OR ESTER THEREOF

An antivirally active pharmaceutical oil-in-water emulsion containing 9-[(2-hydroxyethoxy)methyl]guanine (acyclovir) or a salt or ester thereof as an active ingredient in the continuous aqueous phase, said phase in addition to said active ingredient and the dispersed oil phase containing a water miscible organic solvent, wherein a polyhydric alcohol may form a constituent. The emulsion comprises from 1 % to 10 % w/w of acyclovir or a salt or ester thereof, from 20 % to 50 % w/w of organic solvent comprising from 5 % to 50 % w/w glycerol formal and from 0 % to 29 % w/w of a polyhydric alcohol, and from 20 % to 40 % w/w water, said percentages being based on the total weight of the formulation. As a polyhydric alcohol propylene glycol may be used, and the emulsion may be available as a cream, wherein the oil phase comprises white vaseline, liquid paraffin (paraffin oil), glycerol monostearate, and stearic acid. An antivirally active pharmaceutical oil-in-water emulsion containing 9-((2-hydroxyethoxy)methyl)guanine (acyclovir) or a salt or ester thereof as an active ingredient in the continuous aqueous phase, said phase in addition to said active ingredient and the dispersed oil phase containing a water miscible organic solvent, wherein a polyhydric alcohol may form a constituent. The emulsion comprises from 1 % to 10 % w/w of acyclovir or a salt or ester thereof, from 20 % to 50 % w/w of organic solvent comprising from 5 % to 50 % w/w glycerol formal and from 0 % to 29 % w/w of a polyhydric alcohol, and from 20 % to 40 % w/w water, said percentages being based on the total weight of the formulation. As a polyhydric alcohol propylene glycol may be used, and the emulsion may be available as a cream, wherein the oil phase comprises white vaseline, liquid paraffin (paraffin oil), glycerol monostearate, and stearic acid. Emulsion pharmaceutique d'huile dans l'eau à action antivirale contenant de la 9-[(2-hydroxyéthoxy)méthyl]guanine (acyclovir) ou un sel ou ester de la ladite substance en tant qu'ingrédient actif dans la phase aqueuse continue, ladite phase, en plus dudit ingrédient actif et de la phase huileuse dispersée, contenant un solvant organique hydrosoluble, un alcool polyvalent pouvant former un constituant. Ladite émulsion contient de 1 % à 10 % en poids d'acyclovir ou d'un sel ou ester de cette substance, de 20 % à 50 % en poids de solvant organique comprenant de 5 % à 50 % en poids de formal de glycérol et de 0 % à 29 % en poids d'un alcool polyvalen