BIPHENYLALKYL XANTHINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS

A class of non-peptidic biphenylalkyl xanthine compounds is described for use in treatment of cardiovascular disorders. Compounds of particular interest are angiotensin II antagonists of formula (I) wherein each of X and X is independently selected from oxygen atom and sulfur atom; wherein m is one; wherein each of R and R is independently selected from hydrido, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 4-methylbutyl, n-pentyl, neopentyl, methoxycarbonylmethyl, methoxycarbonylethyl, cyclopropylmethyl, cyclopropylethyl, propenyl, phenyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, 4-hydroxybutyl, 2-hydroxyethyl and 3-hydroxypropyl; wherein R is selected from ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, 4-methylbutyl, tert-butyl, n-pentyl, neopentyl, 2-cyclohexylethyl, benzyl, 2-phenylethyl, 3-phenylpropyl, cyclohexylmethyl, cyclohexyl, propoxy, butoxy, 1-butenyl, buten-2-yl, 3-butenyl, butyn-1-yl, butyn-2-yl, butyn-3-yl, propylthio and butylthio; wherein each of R through R is hydrido with the proviso that at lest one of R , R , R and R is an acidic group selected from CO2H, SH, PO3H2, SO3H, CONHNH2, CONHNHSO2CF3, OH, NHSO2CH3, NHSO2CF3, NHCOCF3, CONHSO2C6H5, CONHOH, CONHOCH3, CONHSO2CH3 and tetrazole; or a tautomer thereof or a pharmaceutically-acceptable salt thereof. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure. On décrit une catégorie de composés de xanthine de biphénylalkyle non peptidiques destinés à être utilisés dans le traitement de troubles cardiovasculaires. Des composés particulièrement utiles sont les antagonistes de l'angiotensine II de la formule (I) dans laquelle X1 et X2 sont toujours choisis indépendamment parmi un atome d'oxygène ou un atome de soufre; dans laquelle m est un; dans laquelle R0 et R1 sont toujours choisis indépendamment parmi hydrido, méthyle, éthyle, n-propyle, isopropyle, n-butyle, sec-butyle, isobutyle, tert-butyle, 4-méthylbutyle, n-pentyle, néopentyle, méthoxycarbonylméthyle, méthoxycarbonyléthyle, cyclopropylméthyle, cyclopropyléthyle, pronényle, phényle, benzyle, phénéthyle, cyclohexyle, cyclohexylméthyle, 4-hydroxybutyle, 2-hydroxyéthyle et 3-hydroxypropyle; dans laquelle R2 est choisi parmi éthyle, n-propyle, isopropyle, n-butyle, sec-butyle, isobutyle, 4-méthylbutyle, tert-butyle, n-pentyle, néopentyle, 2-cyclohexyléthyle, benzyle, 2-phényléthyle, 3-phénylpropyle, cyclohexylméthyle, cyclohexyle, pr