MODIFIED HUMAN TNFALPHA (TUMOR NECROSIS FACTOR ALPHA) RECEPTOR

A polypeptide which is capable of binding human TNF alpha and which consists essentially of: a) the first three cysteine-rich subdomains, but not the fourth cysteine-rich subdomain, of the extracellular binding domain of the 55kD or 75kD receptor for human TNF alpha ; or b) an amino acid sequence ha...

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Bibliographische Detailangaben
Hauptverfasser:	TURNER, MARTIN, JOHN, CHARLES, GRAY, PATRICK, WILLIAM, FELDMANN, MARC, BRENNAN, FIONULA, MARY
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A polypeptide which is capable of binding human TNF alpha and which consists essentially of: a) the first three cysteine-rich subdomains, but not the fourth cysteine-rich subdomain, of the extracellular binding domain of the 55kD or 75kD receptor for human TNF alpha ; or b) an amino acid sequence having a homology of 90 % or more with the said sequence (a). Polypeptide pouvant se lier au facteur de Nécrose Tumorale alpha (TNFalpha) humain et qui se compose essentiellement de: A) les trois premiers sous-domaines riches en cystéine, mais pas le quatrième sous-domaine riche en cystéine, du domaine de liaison extracellulaire du reécepteur de 55KD ou 75KD du TNFalpha humain; ou b) une séquence d'acides aminés présentant une homologie de 90 % ou plus avec ladite séquence (a).