CILIARY NEUROTROPHIC FACTOR

The present invention relates to nucleic acid sequences encoding ciliary neurotrophic factor (CNTF) and to the proteins, peptides, and derivatives produced therefrom. In various embodiments of the invention, the nucleic acid sequences, proteins, and peptides of the invention may be used in the treat...

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Bibliographische Detailangaben
Hauptverfasser:	FURTH, MARK, E, STOCKLI-RIPPSTEIN, KURT, A, WONG, VIVIEN, CARROLL, PATRICK, DESMOND, GOTZ, RUDOLF, GEORG, KREUTZBERG, GEORG, W, MASIAKOWSKI, PIOTR, LOTTSPEICH, FRIEDRICH, THOENEN, HANS, FRIEDRICH, ERWIN, SENDTNER, MICHAEL, ARAKAWA, YOSHIHIRO, IP, NANCY, PANAYOTATOS, NIKOS, LINDHOLM, DAN, B
Format:	Patent
Sprache:	eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to nucleic acid sequences encoding ciliary neurotrophic factor (CNTF) and to the proteins, peptides, and derivatives produced therefrom. In various embodiments of the invention, the nucleic acid sequences, proteins, and peptides of the invention may be used in the treatment of a variety of neurological diseases and disorders, including Alzheimer's disease. In a specific embodiment of the invention, CNTF may be used to support the growth of spinal cord neurons, thereby providing a method of treating spinal cord damage caused by trauma infarction, infection, nutritional deficiency or toxic agents. The present invention also relates to a novel method for producing substantially pure CNTF. The invention also relates to pharmaceutical compositions comprising effective amounts of CNTF gene products which may be used in the diagnosis and treatment of a variety of neurological diseases and disorders. The present invention relates to the cloning sequencing and expression of CNTF and provides, for the first time, a means for producing human CNTF utilizing human CNTF-encoding nucleic acid sequences. Furthermore, the CNTF nucleic acid sequences of the invention may be utilized to identify nucleic acid sequences encoding CNTF or CNTF-homologous molecules in a variety of species and tissues. L'invention concerne des séquences d'acide nucléique codant le facteur neurotrophique ciliaire (CNTF) et des protéines, des peptides et des dérivés produits à partir de celui-ci. Dans plusieurs modes de réalisation de l'invention, les séquences d'acide nucléique, les protéines et les peptides de l'invention peuvent être utilisés dans le traitement d'une variété de maladies et troubles neurologiques, y compris la maladie d'Alzheimer. Dans un mode spécifique de réalisation de l'invention, CNTF peut être utilisé comme support de la croissance des neurones du cordon médullaire, constituant ainsi un procédé pour traiter les dégâts subis par le cordon médullaire et provoqué par un infarctus traumatique, une infection, une déficience nutritive ou des agents toxiques. La présente invention concerne également un nouveau procédé de production de CNTF sensiblement pur. L'invention concerne aussi des compositions pharmaceutiques comprenant des quantités efficaces de produit génétique de CNTF qui peuvent être utilisés dans le diagnostic et le traitement d'une variété de maladies et troubles neurologiques. La présente invention concerne le clonage, la mise en séquenc