DLL3 TARGETING PEPTIDES AND CONSTRUCTS THEREOF

DLL3 TARGETING PEPTIDES AND CONSTRUCTS THEREOF

The present disclosure relates to targeting moieties such as peptides that can bind to DLL3. The disclosure also provides targeting constructs, which may include a targeting moiety attached, via an optional linker, to a chelating agent for association of a cargo. Methods of making the constructs and...

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Bibliographische Detailangaben
Hauptverfasser: HUANG, Chunhui, BRANCA, Danila, RICARDO, Alonso, COSTANTE, Roberto, WU, Lihua, MA, Zhong, BRUTON, Thomas C, METCALF III, Chester A, WAN, Murray
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure relates to targeting moieties such as peptides that can bind to DLL3. The disclosure also provides targeting constructs, which may include a targeting moiety attached, via an optional linker, to a chelating agent for association of a cargo. Methods of making the constructs and formulations thereof are also provided. Methods of using the constructs and/or formulations thereof to treat subjects, for example, to treat or prevent cancer, are also described. La présente divulgation concerne des fractions de ciblage telles que des peptides qui peuvent se lier à DLL3. La divulgation concerne également des constructions de ciblage, qui peuvent comprendre une fraction de ciblage fixée, par l'intermédiaire d'un lieur facultatif, à un agent chélatant pour l'association d'un chargement. L'invention concerne également des procédés de fabrication des constructions et des formulations de celles-ci. L'invention concerne en outre des méthodes d'utilisation des constructions et/ou des formulations de celles-ci pour traiter des sujets, par exemple, pour traiter ou prévenir le cancer.