METHOD FOR PREPARING ANTIBODY-DRUG CONJUGATE

The present invention relates to a method for preparing an antibody-drug conjugate. According to the method, a highly homogeneous antibody conjugate molecule is obtained by means of a specific chemical site-directed conjugation method, and the proportion of a DAR2 main peak thereof reaches 99% or ab...

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Bibliographische Detailangaben
Hauptverfasser:	TAN, Xiaoding, WANG, Zhenzhen, ZHOU, Wei, ZHU, Huikai, CHEN, Yuhang
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to a method for preparing an antibody-drug conjugate. According to the method, a highly homogeneous antibody conjugate molecule is obtained by means of a specific chemical site-directed conjugation method, and the proportion of a DAR2 main peak thereof reaches 99% or above. The preparation method of the present invention has few steps, and is easy to operate, and is thus beneficial for industrial scaled-up production. In addition, the prepared product has few impurities and a high purity, the medication safety is obviously improved, and the production cost is also reduced. La présente invention concerne un procédé de préparation d'un conjugué anticorps-médicament. Selon le procédé, une molécule conjuguée d'anticorps hautement homogène est obtenue au moyen d'un procédé de conjugaison dirigée par site chimique spécifique, et la proportion d'un pic principal de DAR2 de celle-ci atteint 99% ou plus. Le procédé de préparation de la présente invention présente peu d'étapes, et est faci