CHIMERIC ANTIGEN RECEPTOR COMPRISING NOVEL CO-STIMULATORY DOMAIN AND USE THEREOF

The present invention relates to a chimeric antigen receptor, comprising a ligand binding domain, a transmembrane domain, a co-stimulatory domain, and an intracellular signaling domain, wherein the co-stimulatory domain comprises a mutated CD27 intracellular region. The present invention also relate...

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Bibliographische Detailangaben
Hauptverfasser:	TANG, Yingxiu, REN, Jiangtao, ZHOU, Yali, ZHENG, Dong
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a chimeric antigen receptor, comprising a ligand binding domain, a transmembrane domain, a co-stimulatory domain, and an intracellular signaling domain, wherein the co-stimulatory domain comprises a mutated CD27 intracellular region. The present invention also relates to an engineered immune cell comprising the chimeric antigen receptor, and a use thereof in treatment of diseases, such as cancer, autoimmune diseases, infections. La présente invention concerne un récepteur antigénique chimérique, comprenant un domaine de liaison à un ligand, un domaine transmembranaire, un domaine de costimulation et un domaine de signalisation intracellulaire, le domaine de costimulation comprenant une région intracellulaire CD27 mutée. La présente invention concerne également une cellule immunitaire modifiée comprenant le récepteur antigénique chimérique, et son utilisation dans le traitement de maladies, telles que le cancer, les maladies auto-immunes, les infections. 本发明涉及一种嵌合抗原受体，其包含配体结合结构