ADENO-ASSOCIATED VIRUS FORMULATIONS

Pharmaceutical compositions comprising adeno-associated virus (AAV) are provided herein. In some aspects, the pharmaceutical compositions comprise about 5 mM to about 20 mM Tris buffer, about 100 mM to about 250 mM sodium chloride, about 0.001 % (w/v) to about 0.01 % (w/v) Pluronic F68, and has a pH...

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Bibliographische Detailangaben
Hauptverfasser:	GONZALES, Johnny C, BARGLOW, Catherine T
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Pharmaceutical compositions comprising adeno-associated virus (AAV) are provided herein. In some aspects, the pharmaceutical compositions comprise about 5 mM to about 20 mM Tris buffer, about 100 mM to about 250 mM sodium chloride, about 0.001 % (w/v) to about 0.01 % (w/v) Pluronic F68, and has a pH between 7.0 and 9.0. Methods of preparing a pharmaceutical composition comprising AAV, methods of treating a VEGF-associated disorder in a subject, and methods of storing AAV compositions are also provided. L'invention concerne des compositions pharmaceutiques comprenant le virus adéno-associé (AAV). Selon certains aspects, les compositions pharmaceutiques comprennent environ 5 mM à environ 20 mM de tampon Tris, environ 100 mM à environ 250 mM de chlorure de sodium, environ 0,001 % (p/v) à environ 0,01 % (p/v) de Pluronic F68, et présentent un pH compris entre 7,0 et 9,0. La présente invention concerne également des procédés de préparation d'une composition pharmaceutique contenant des AAV, des procédés de traitement d'un trouble associé au VEGF chez un sujet et des procédés de stockage de compositions d'AAV.