ANTIBODY BINDING TISSUE FACTOR PATHWAY INHIBITOR AND USE OF ANTIBODY

Provided is an antibody specifically binding a tissue factor pathway inhibitor in a pH-dependent manner or an antigen-binding fragment of the antibody, and also provided are a nucleic acid molecule encoding the antibody, an expression vector and a host cell for expressing the antibody, and a product...

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Bibliographische Detailangaben
Hauptverfasser:	WU, Cui, ZHOU, Chi, LI, Yuanli, LI, Qiang, CHEN, Si, DIAO, Jiasheng, SUN, Jianyu, GAO, Yongjuan
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided is an antibody specifically binding a tissue factor pathway inhibitor in a pH-dependent manner or an antigen-binding fragment of the antibody, and also provided are a nucleic acid molecule encoding the antibody, an expression vector and a host cell for expressing the antibody, and a production method for the antibody. In addition, also provided are a pharmaceutical composition comprising the antibody or the antigen-binding fragment thereof, and a use of the pharmaceutical composition in the preparation of patient therapeutic drugs for preventing and/or treating diseases such as genetic or acquired coagulation factor deficiency, Bernard-Soulier syndrome, and Glanzmann's thrombasthenia. L'invention concerne un anticorps se liant spécifiquement à un inhibiteur de la voie du facteur tissulaire de manière dépendante du pH ou un fragment de liaison à l'antigène de l'anticorps, et l'invention concerne également une molécule d'acide nucléique codant pour l'anticorps, un vecteur d'expression et une cellule hô