RNA VACCINES ENCODING HERPES SIMPLEX VIRUS GLYCOPROTEINS AND USES THEREOF

The present disclosure provides compositions for the prevention and treatment of genital herpes, comprising nucleoside modified RNAs that encode herpes simplex virus (HSV) glycoproteins, including those involved in virus entry and immune evasion, and methods of use thereof. La présente divulgation c...

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Bibliographische Detailangaben
Hauptverfasser:	LUBINSKI, John, COHEN, Gary H, GÜLER, Alptekin, FRIEDMAN, Harvey, AWASTHI, Sita, VELAZQUEZ, Ricardo Sanchez, HINZ, Sabrina, DANY, Sarah Catharina, UEBELE, Julia, HEIN, Stephanie, EGAN, Kevin, WEISSMAN, Drew, PFAFENROT, Christina, VOGEL, Annette, ERNST, Anna Luise
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure provides compositions for the prevention and treatment of genital herpes, comprising nucleoside modified RNAs that encode herpes simplex virus (HSV) glycoproteins, including those involved in virus entry and immune evasion, and methods of use thereof. La présente divulgation concerne des compositions pour la prévention et le traitement de l'herpès génital, comprenant des ARN modifiés par des nucléosides qui codent pour des glycoprotéines du virus de l'herpès simplex (VHS), y compris celles impliquées dans l'entrée et l'évasion immunitaire du virus, ainsi que des procédés d'utilisation associés.