COMPOUNDS, COMPOSITIONS, AND METHODS

COMPOUNDS, COMPOSITIONS, AND METHODS

The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NLRP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and met...

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Bibliographische Detailangaben
Hauptverfasser: FOX, Brian M, HUFFMAN, Benjamin J, BAGDASARIAN, Alex L, DE VICENTE FIDALGO, Javier, CRAIG, II, LEXA, Katrina W
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NLRP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof. La présente divulgation concerne de manière générale des modulateurs à petites molécules de NLRP3 (NLR Family Pyrin Domain Containing 3), ou un sel pharmaceutiquement acceptable, un analogue enrichi isotopiquement, un stéréoisomère, un mélange de stéréoisomères, ou un promédicament de ceux-ci, des procédés de fabrication et des intermédiaires de ceux-ci, et des procédés d'utilisation de ceux-ci.