SOLID DISPERSION OF MYELOID KINOME INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

A solid dispersion of 5-chloro-N-(3-cyclopropyl-5-{[(3R,5S)-dimethylpiperazin-1-yl]methyl}phenyl)-4-(6-methyl-1H-indol-3-yl)pyrimidin-2-amine and processes for preparing the solid dispersion are provided herein. Also, a pharmaceutical composition comprising a solid dispersion of 5-chloro-N-(3-cyclop...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	LEE, Kwangyoung, KWON, Taekkwan, KIM, Yongil
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A solid dispersion of 5-chloro-N-(3-cyclopropyl-5-{[(3R,5S)-dimethylpiperazin-1-yl]methyl}phenyl)-4-(6-methyl-1H-indol-3-yl)pyrimidin-2-amine and processes for preparing the solid dispersion are provided herein. Also, a pharmaceutical composition comprising a solid dispersion of 5-chloro-N-(3-cyclopropyl-5-{[(3R,5S)-dimethylpiperazin-1-yl]methyl}phenyl)-4-(6-methyl-1H-indol-3-yl)pyrimidin-2-amine and uses thereof are provided herein. L'invention concerne une dispersion solide de 5-chloro-N-(3-cyclopropyl-5-{[(3R,5S)-diméthylpipérazin-1-yl]méthyl}phényl)-4-(6-méthyl-1H-indol-3-yl)pyrimidin-2-amine et des procédés de préparation de la dispersion solide. L'invention concerne également une composition pharmaceutique comprenant une dispersion solide de 5-chloro-N-(3-cyclopropyl-5-{[(3R,5S)-diméthylpipérazin-1-yl]méthyl}phényl)-4-(6-méthyl-1H-indol-3-yl)pyrimidin-2-amine et ses utilisations.