INHIBITORS OF CANINE JANUS KINASE AND USES THEREOF

Provided herein are compounds having inhibitory activity toward the Janus Kinase 1 (JAK-1) enzyme, and which are useful as therapeutic and/or prophylactic agents. The compounds may be useful in treating inflammatory disorders in non-human mammals, for example, in treating canine atopic dermatitis. A...

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Bibliographische Detailangaben
Hauptverfasser:	CALABRESE, Andrew Antony, STANTON, David T
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Provided herein are compounds having inhibitory activity toward the Janus Kinase 1 (JAK-1) enzyme, and which are useful as therapeutic and/or prophylactic agents. The compounds may be useful in treating inflammatory disorders in non-human mammals, for example, in treating canine atopic dermatitis. Also provided herein are methods for preparation of such compounds. L'invention concerne des composés ayant une activité inhibitrice vis-à-vis de l'enzyme Janus Kinase 1 (JAK-1), et qui sont utiles en tant qu'agents thérapeutiques et/ou prophylactiques. Les composés peuvent être utiles dans le traitement de troubles inflammatoires chez des mammifères non humains, par exemple, dans le traitement de la dermatite atopique canine. L'invention concerne également des procédés de préparation de tels composés.