SPIROCYCLIC ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, ring A, ring B, p, q, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and thei...
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| creator | MANTOULIDIS, Andreas SARKAR, Dhruba LITTLE, Andrew BROEKER, Joachim SOKOL, Kevin CUI, Jianwen RAMHARTER, Juergen WATERSON, Alex HERDEIS, Lorenz FESIK, Stephen W WUNBERG, Tobias ABBOTT, Jason HODGES, Tim GOLLNER, Andreas |
| description | The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, ring A, ring B, p, q, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
La présente invention concerne des composés représentés par la formule (I), dans laquelle R1a, R1b, R2a, R2b, Z, R3 à R5, le cycle A, le cycle B, p, q, V et W ont les significations données dans les revendications et la description, leur utilisation en tant qu'inhibiteurs de KRAS, des compositions pharmaceutiques et des préparations contenant de tels composés et leur utilisation en tant que médicaments/utilisations médicales, en particulier en tant qu'agents pour le traitement et/ou la prévention de maladies oncologiques. |
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La présente invention concerne des composés représentés par la formule (I), dans laquelle R1a, R1b, R2a, R2b, Z, R3 à R5, le cycle A, le cycle B, p, q, V et W ont les significations données dans les revendications et la description, leur utilisation en tant qu'inhibiteurs de KRAS, des compositions pharmaceutiques et des préparations contenant de tels composés et leur utilisation en tant que médicaments/utilisations médicales, en particulier en tant qu'agents pour le traitement et/ou la prévention de maladies oncologiques.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241205&DB=EPODOC&CC=WO&NR=2024246099A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241205&DB=EPODOC&CC=WO&NR=2024246099A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MANTOULIDIS, Andreas</creatorcontrib><creatorcontrib>SARKAR, Dhruba</creatorcontrib><creatorcontrib>LITTLE, Andrew</creatorcontrib><creatorcontrib>BROEKER, Joachim</creatorcontrib><creatorcontrib>SOKOL, Kevin</creatorcontrib><creatorcontrib>CUI, Jianwen</creatorcontrib><creatorcontrib>RAMHARTER, Juergen</creatorcontrib><creatorcontrib>WATERSON, Alex</creatorcontrib><creatorcontrib>HERDEIS, Lorenz</creatorcontrib><creatorcontrib>FESIK, Stephen W</creatorcontrib><creatorcontrib>WUNBERG, Tobias</creatorcontrib><creatorcontrib>ABBOTT, Jason</creatorcontrib><creatorcontrib>HODGES, Tim</creatorcontrib><creatorcontrib>GOLLNER, Andreas</creatorcontrib><title>SPIROCYCLIC ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER</title><description>The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, ring A, ring B, p, q, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
La présente invention concerne des composés représentés par la formule (I), dans laquelle R1a, R1b, R2a, R2b, Z, R3 à R5, le cycle A, le cycle B, p, q, V et W ont les significations données dans les revendications et la description, leur utilisation en tant qu'inhibiteurs de KRAS, des compositions pharmaceutiques et des préparations contenant de tels composés et leur utilisation en tant que médicaments/utilisations médicales, en particulier en tant qu'agents pour le traitement et/ou la prévention de maladies oncologiques.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNisEKgkAQQL10iOofFjov2CqBx2GcxQWdlXUyhEAktlOUYP9PHvqATo_He9vk1rUueBywdqiA-VKDUKmMhsax15nGAdgrqZxvK2Lq1qlUJQXXg7h-devDmklJIJCGWJS3CoGRwj7ZPKbnEg8_7pKjJcFKx_k9xmWe7vEVP-PVm9TkJj-nRQGn7L_rC2DZMwY</recordid><startdate>20241205</startdate><enddate>20241205</enddate><creator>MANTOULIDIS, Andreas</creator><creator>SARKAR, Dhruba</creator><creator>LITTLE, Andrew</creator><creator>BROEKER, Joachim</creator><creator>SOKOL, Kevin</creator><creator>CUI, Jianwen</creator><creator>RAMHARTER, Juergen</creator><creator>WATERSON, Alex</creator><creator>HERDEIS, Lorenz</creator><creator>FESIK, Stephen W</creator><creator>WUNBERG, Tobias</creator><creator>ABBOTT, Jason</creator><creator>HODGES, Tim</creator><creator>GOLLNER, Andreas</creator><scope>EVB</scope></search><sort><creationdate>20241205</creationdate><title>SPIROCYCLIC ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER</title><author>MANTOULIDIS, Andreas ; SARKAR, Dhruba ; LITTLE, Andrew ; BROEKER, Joachim ; SOKOL, Kevin ; CUI, Jianwen ; RAMHARTER, Juergen ; WATERSON, Alex ; HERDEIS, Lorenz ; FESIK, Stephen W ; WUNBERG, Tobias ; ABBOTT, Jason ; HODGES, Tim ; GOLLNER, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024246099A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MANTOULIDIS, Andreas</creatorcontrib><creatorcontrib>SARKAR, Dhruba</creatorcontrib><creatorcontrib>LITTLE, Andrew</creatorcontrib><creatorcontrib>BROEKER, Joachim</creatorcontrib><creatorcontrib>SOKOL, Kevin</creatorcontrib><creatorcontrib>CUI, Jianwen</creatorcontrib><creatorcontrib>RAMHARTER, Juergen</creatorcontrib><creatorcontrib>WATERSON, Alex</creatorcontrib><creatorcontrib>HERDEIS, Lorenz</creatorcontrib><creatorcontrib>FESIK, Stephen W</creatorcontrib><creatorcontrib>WUNBERG, Tobias</creatorcontrib><creatorcontrib>ABBOTT, Jason</creatorcontrib><creatorcontrib>HODGES, Tim</creatorcontrib><creatorcontrib>GOLLNER, Andreas</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MANTOULIDIS, Andreas</au><au>SARKAR, Dhruba</au><au>LITTLE, Andrew</au><au>BROEKER, Joachim</au><au>SOKOL, Kevin</au><au>CUI, Jianwen</au><au>RAMHARTER, Juergen</au><au>WATERSON, Alex</au><au>HERDEIS, Lorenz</au><au>FESIK, Stephen W</au><au>WUNBERG, Tobias</au><au>ABBOTT, Jason</au><au>HODGES, Tim</au><au>GOLLNER, Andreas</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SPIROCYCLIC ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER</title><date>2024-12-05</date><risdate>2024</risdate><abstract>The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, ring A, ring B, p, q, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
La présente invention concerne des composés représentés par la formule (I), dans laquelle R1a, R1b, R2a, R2b, Z, R3 à R5, le cycle A, le cycle B, p, q, V et W ont les significations données dans les revendications et la description, leur utilisation en tant qu'inhibiteurs de KRAS, des compositions pharmaceutiques et des préparations contenant de tels composés et leur utilisation en tant que médicaments/utilisations médicales, en particulier en tant qu'agents pour le traitement et/ou la prévention de maladies oncologiques.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SPIROCYCLIC ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER |
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