SPIROCYCLIC ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER

The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, ring A, ring B, p, q, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and thei...

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Bibliographische Detailangaben
Hauptverfasser:	MANTOULIDIS, Andreas, SARKAR, Dhruba, LITTLE, Andrew, BROEKER, Joachim, SOKOL, Kevin, CUI, Jianwen, RAMHARTER, Juergen, WATERSON, Alex, HERDEIS, Lorenz, FESIK, Stephen W, WUNBERG, Tobias, ABBOTT, Jason, HODGES, Tim, GOLLNER, Andreas
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, ring A, ring B, p, q, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases. La présente invention concerne des composés représentés par la formule (I), dans laquelle R1a, R1b, R2a, R2b, Z, R3 à R5, le cycle A, le cycle B, p, q, V et W ont les significations données dans les revendications et la description, leur utilisation en tant qu'inhibiteurs de KRAS, des compositions pharmaceutiques et des préparations contenant de tels composés et leur utilisation en tant que médicaments/utilisations médicales, en particulier en tant qu'agents pour le traitement et/ou la prévention de maladies oncologiques.