COCHLEAR HAIR CELL SPECIFIC PROMOTER AND USE THEREOF
The present invention relates to a cochlear hair cell specific promoter and the use thereof. The present invention particularly relates to a nucleic acid promoter (SEQ ID NO: 1), the nucleic acid promoter comprising an enhancer sequence (SEQ ID NO: 2) and a core promoter element (SEQ ID NO: 3), wher...
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| creator | SUN, Sijie QI, Jieyu ZHANG, Liyan TAN, Chang ZHANG, Shanzhong SONG, Huaien CUI, Zhiping TAN, Fangzhi JIANG, Lulu CHAI, Renjie LU, Ling |
| description | The present invention relates to a cochlear hair cell specific promoter and the use thereof. The present invention particularly relates to a nucleic acid promoter (SEQ ID NO: 1), the nucleic acid promoter comprising an enhancer sequence (SEQ ID NO: 2) and a core promoter element (SEQ ID NO: 3), wherein the enhancer sequence has a sequence shown as SEQ ID NO: 2 or a sequence having at least 90% sequence identity with same, and the core promoter element has a sequence shown as SEQ ID NO: 3 or a sequence having at least 90% sequence identity with same. The promoter (SEQ ID NO: 1) can specifically guide gene expression in cochlear hair cells.
La présente invention concerne un promoteur spécifique des cellules ciliées cochléaires et son utilisation. La présente invention concerne plus particulièrement un promoteur d'acide nucléique (SEQ ID NO : 1), le promoteur d'acide nucléique contenant une séquence activatrice (SEQ ID NO : 2) et un élément promoteur central (SEQ ID NO : 3), la séquence activatrice présentant un |
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La présente invention concerne un promoteur spécifique des cellules ciliées cochléaires et son utilisation. La présente invention concerne plus particulièrement un promoteur d'acide nucléique (SEQ ID NO : 1), le promoteur d'acide nucléique contenant une séquence activatrice (SEQ ID NO : 2) et un élément promoteur central (SEQ ID NO : 3), la séquence activatrice présentant un</description><language>chi ; eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241128&DB=EPODOC&CC=WO&NR=2024239226A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241128&DB=EPODOC&CC=WO&NR=2024239226A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SUN, Sijie</creatorcontrib><creatorcontrib>QI, Jieyu</creatorcontrib><creatorcontrib>ZHANG, Liyan</creatorcontrib><creatorcontrib>TAN, Chang</creatorcontrib><creatorcontrib>ZHANG, Shanzhong</creatorcontrib><creatorcontrib>SONG, Huaien</creatorcontrib><creatorcontrib>CUI, Zhiping</creatorcontrib><creatorcontrib>TAN, Fangzhi</creatorcontrib><creatorcontrib>JIANG, Lulu</creatorcontrib><creatorcontrib>CHAI, Renjie</creatorcontrib><creatorcontrib>LU, Ling</creatorcontrib><title>COCHLEAR HAIR CELL SPECIFIC PROMOTER AND USE THEREOF</title><description>The present invention relates to a cochlear hair cell specific promoter and the use thereof. The present invention particularly relates to a nucleic acid promoter (SEQ ID NO: 1), the nucleic acid promoter comprising an enhancer sequence (SEQ ID NO: 2) and a core promoter element (SEQ ID NO: 3), wherein the enhancer sequence has a sequence shown as SEQ ID NO: 2 or a sequence having at least 90% sequence identity with same, and the core promoter element has a sequence shown as SEQ ID NO: 3 or a sequence having at least 90% sequence identity with same. The promoter (SEQ ID NO: 1) can specifically guide gene expression in cochlear hair cells.
La présente invention concerne un promoteur spécifique des cellules ciliées cochléaires et son utilisation. La présente invention concerne plus particulièrement un promoteur d'acide nucléique (SEQ ID NO : 1), le promoteur d'acide nucléique contenant une séquence activatrice (SEQ ID NO : 2) et un élément promoteur central (SEQ ID NO : 3), la séquence activatrice présentant un</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDBx9nf28HF1DFLwcPQMUnB29fFRCA5wdfZ083RWCAjy9_UPcQ1ScPRzUQgNdlUI8XANcvV342FgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgZGJkbGlkZGZo6GxsSpAgA8LSf7</recordid><startdate>20241128</startdate><enddate>20241128</enddate><creator>SUN, Sijie</creator><creator>QI, Jieyu</creator><creator>ZHANG, Liyan</creator><creator>TAN, Chang</creator><creator>ZHANG, Shanzhong</creator><creator>SONG, Huaien</creator><creator>CUI, Zhiping</creator><creator>TAN, Fangzhi</creator><creator>JIANG, Lulu</creator><creator>CHAI, Renjie</creator><creator>LU, Ling</creator><scope>EVB</scope></search><sort><creationdate>20241128</creationdate><title>COCHLEAR HAIR CELL SPECIFIC PROMOTER AND USE THEREOF</title><author>SUN, Sijie ; QI, Jieyu ; ZHANG, Liyan ; TAN, Chang ; ZHANG, Shanzhong ; SONG, Huaien ; CUI, Zhiping ; TAN, Fangzhi ; JIANG, Lulu ; CHAI, Renjie ; LU, Ling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024239226A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng ; fre</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SUN, Sijie</creatorcontrib><creatorcontrib>QI, Jieyu</creatorcontrib><creatorcontrib>ZHANG, Liyan</creatorcontrib><creatorcontrib>TAN, Chang</creatorcontrib><creatorcontrib>ZHANG, Shanzhong</creatorcontrib><creatorcontrib>SONG, Huaien</creatorcontrib><creatorcontrib>CUI, Zhiping</creatorcontrib><creatorcontrib>TAN, Fangzhi</creatorcontrib><creatorcontrib>JIANG, Lulu</creatorcontrib><creatorcontrib>CHAI, Renjie</creatorcontrib><creatorcontrib>LU, Ling</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SUN, Sijie</au><au>QI, Jieyu</au><au>ZHANG, Liyan</au><au>TAN, Chang</au><au>ZHANG, Shanzhong</au><au>SONG, Huaien</au><au>CUI, Zhiping</au><au>TAN, Fangzhi</au><au>JIANG, Lulu</au><au>CHAI, Renjie</au><au>LU, Ling</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COCHLEAR HAIR CELL SPECIFIC PROMOTER AND USE THEREOF</title><date>2024-11-28</date><risdate>2024</risdate><abstract>The present invention relates to a cochlear hair cell specific promoter and the use thereof. The present invention particularly relates to a nucleic acid promoter (SEQ ID NO: 1), the nucleic acid promoter comprising an enhancer sequence (SEQ ID NO: 2) and a core promoter element (SEQ ID NO: 3), wherein the enhancer sequence has a sequence shown as SEQ ID NO: 2 or a sequence having at least 90% sequence identity with same, and the core promoter element has a sequence shown as SEQ ID NO: 3 or a sequence having at least 90% sequence identity with same. The promoter (SEQ ID NO: 1) can specifically guide gene expression in cochlear hair cells.
La présente invention concerne un promoteur spécifique des cellules ciliées cochléaires et son utilisation. La présente invention concerne plus particulièrement un promoteur d'acide nucléique (SEQ ID NO : 1), le promoteur d'acide nucléique contenant une séquence activatrice (SEQ ID NO : 2) et un élément promoteur central (SEQ ID NO : 3), la séquence activatrice présentant un</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | COCHLEAR HAIR CELL SPECIFIC PROMOTER AND USE THEREOF |
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