INDAZOLYL-CONTAINING HYDROXAMIC ACID DERIVATIVE AND USE THEREOF

Disclosed in the present invention is a compound as shown in general formula (I), a pharmaceutically acceptable salt, hydrate or prodrug thereof, and the use thereof in the preparation of a drug for preventing and/or treating diseases mediated by tyrosine kinase and/or histone deacetylase. The compo...

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Bibliographische Detailangaben
Hauptverfasser:	FENG, Zixia, CAO, Zhenghong
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed in the present invention is a compound as shown in general formula (I), a pharmaceutically acceptable salt, hydrate or prodrug thereof, and the use thereof in the preparation of a drug for preventing and/or treating diseases mediated by tyrosine kinase and/or histone deacetylase. The compound can simultaneously play a good inhibitory role against a variety of targets (especially histone deacetylase 1, histone deacetylase 6, and two tyrosine kinases (vascular endothelial growth factor receptor and platelet-derived growth factor receptor)), and is expected to be used in the treatment of malignant tumors. La présente invention concerne un composé tel que représenté dans la formule générale (I), un sel, hydrate ou promédicament pharmaceutiquement acceptable de celui-ci, et son utilisation dans la préparation d'un médicament pour la prévention et/ou le traitement de maladies médiées par la tyrosine kinase et/ou l'histone désacétylase. Le composé peut jouer simultanément un bon rôle inhibiteur vis-à-vis d